Comparative randomized controlled blind study of the anti-shivering effect of hydrocortisone, granisetron and meperidine in post-spinal anesthesia in patients undergoing cesarean section

Background: it was observed that a considerable proportion of patients undergoing surgery experience intraoperative and postoperative hypothermia and it was found that misregulation of body temperature due to anesthesia as well as the cold temperature of the operation room were the main cause

Purpose: to compare the anti-shivering effect of meperidine, hydrocortisone and granisetron after spinal anesthesia during elective cesarean section

Patients and Methods: this study presents a placebo-controlled prospective randomized blind study. Included patients were randomly [using computer generated randomization table] allocated into four equal groups each group consists of 28 patients

Results: in our study, age, sex, and ASA grade distribution of patients were nearly identical in the four groups. Furthermore, the duration of surgery and amount of irrigation fluid used in the four different groups were also similar. We did not observe a change in temperature gradient between the four groups. A study with a more prolonged duration of postoperative temperature monitoring is needed to note if core-periphery temperature changes occur with passage of time

Conclusion: the results indicate that IV granisetron 40 micro g/kg was effective as IV meperidine 0.4 mg/kg and both are slightly effective than IV hydrocortisone 2 mg/kg in reducing the incidence and intensity of shivering during spinal anesthesia compared to control group

Inhibidores de serotonina en el tratamiento de la náusea y el vómito provocados por el tratamiento con quimioterapia antineoplásica / Serotonine inhibitors in the treatment of nausea and vomit provoked for the treatment with antineoplasic chemotherapy

El desarrollo de fármacos antieméticos es una de las áreas más estudiadas en la investigación oncológica. Los avances terapéuticos en este campo pueden resultar en mejoría inmediata de la calidad de vida de los pacientes en tratamiento con quimioterapia antineoplásica. Hace 15 años, los pacientes que recibían tratamiento altamente emetógeno tenían entre 10 y 15 episodios de vómito en las primera 24 horas posquimioterapia. En la actualidad esto se ha reducido de manera significativa y los mecanismos de producción de vómito anticipatorio resultan mejor controlados. Los inhibidores de serotonina representan una línea de tratamiento para la náusea y el vómito en los pacientes con cáncer, pero además han permitido un mayor conocimiento de la fisiopatología de estos trastornos, así como la mejor comprensión de los mecanismos fisiológicos de producción del vómito. A la luz de los distintos tipos de antieméticos, los inhibidores de serotonina representan un alternativa viable en los pacientes que no se benefician con otros tipos de antieméticos. Aunque su eficacia se ha demostrado en diversos estudios, se ha impugnado su uso de forma extensa por su alto costo; sin embargo, el avance en la mejoría de la calidad de vida de los pacientes oncológicos no está sujeto a discusión, por los escasos efectos adversos que provocan y su amplio perfil de seguridad

Effects of the 5-HT receptor antagonists cyanopindolol, ICI 169,369, cisapride and granisetron on neuroleptic-induced catalepsy in mice

Typical neuroleptics (e.g. haloperidol) can induce catalepsy in rodents. Selective 5-hydroxytryptamine1A (5-HT1A) receptor antagonists reduce neuroleptic-induced catalepsy (NIC), suggesting that this subtype of serotonin receptor plays a role in the modulation of nigrostriatal dopaminergic transmission. The present study was designed to evaluate the participation of other 5-HT receptor subtypes in NIC. Adult albino mice (both sexes, 26-35 g) were used. Catalepsy was induced with haloperidol (H; 1.5 mg/kg, ip) and measured at 30-min intervals by means of a bar test. Cyanopindolol (a 5-HT1B receptor antagonist), ICI 169,369 (a 5-HT1C/2 receptor antagonist) and granisetron (a 5-HT3 receptor antagonist) were used. Buspirone, a 5-HT1A partial antagonist, cisapride, a 5-HT3/5-HT4 ligand and clomipramine, a 5-HT neuronal uptake blocker, were also employed. These drugs were injected ip, 20 min before H, with each animal (9-10 per group) used only once. Cyanopindolol (0.3 mg/kg) or ICI 169,369 (5 mg/kg) did not significantly affect NIC (375 +/- 39 and 378 +/- 34 s vs 372 +/- 44 s for controls, at 2 h after H). Buspirone (1 mg/kg) reduced, while pretreatments with either granisetron (0.5 mg/kg), cisapride (5 mg/kg) or clomipramine (5 mg/kg) potentiated the cataleptic effect of H (107 +/- 19, 576 +/- 52, 815 +/- 76 and 800 +/- 97 s vs 374 +/- 40 s in the control group, at 2 h after H).(ABSTRACT TRUNCATED AT 250 WORDS)